Elizabeth (CORMACK) RENFRO – A Nice, Big X Match (Ancestor 45)

Elizabeth (CORMACK) RENFRO – A Nice, Big X Match (Ancestor 45)

If you’ve been studying genetic genealogy for a bit, you may understand X DNA, but I’ll give a summation here.

X DNA is different from regular autosomal DNA. The 23rd chromosomal pair contains the sex chromosomes – those which determine the biological gender of the child. In all but rare cases, biological females have two X chromosomes (XX), and biological males have one X and one Y (XY). As we may have learned in high school or college biology, it is the male’s 23rd chromosome that determines the gender of the child.

Therefore, if the offspring is a male, the father’s Y-DNA has been combined with X-DNA from the mother to create an XY 23rd chromosomal pair. If the offspring is female, the father’s X-DNA has been combined with X-DNA from the mother to create an XX 23rd chromosomal pair. Thus, a male’s X-DNA cannot be passed to any of his male offspring.

So, let’s see how this works.

K and I are an autosomal and X-match. Our trees show that we are 4th cousins. K is female and so am I. We knew already that our most recent common ancestors are Absalom RENFRO (1810-1855) and Elizabeth CORMACK (1809-1901), so this one was pretty easy and is a great illustration of how X-matching works.

K and I match autosomally on Chromosome 15, shown here from my data on DNA Painter.

Absalom and Elizabeth were the parents of 12 biological children and one adopted son (who I suspect was their orphaned grandson). I descend from their son John Marion RENFRO, and K descends from their daughter Mary Esther (RENFRO) SPAULDING.

Because Mary Esther was a daughter of Absalom and Elizabeth (and not a son), she inherited X chromosome DNA from each of her parents. However, because John Marion was a son, he inherited an X from only Elizabeth.

This means that our X-match cannot be from Absalom, it must be from Elizabeth (CORMACK) RENFRO since I could not have inherited any X-DNA from Absalom RENFRO.

So here it is on DNA Painter, on the blue (paternal) half of Chromosome X because the RENFRO/CORMACK line is on my paternal side, and labeled with the proper ancestor:

I love the size of this X-match.

Thus, anyone on my paternal side with whom I have an autosomal and X-match and the matching DNA overlaps the segment on the X where K and I match should be descended from either Elizabeth CORMACK, her parents, or any of her ancestors who could have passed down to her an X-chromosome through her parents, unless the X-match is too small to be valid. Note that the autosomal matching segments do not need to be on Chromosome 15. This is simply where K and I match.

My Chromosome 15 match with K could be with any of our common ancestors. It doesn’t have to be with our X-match Elizabeth CORMACK. Ideally, we would be able to triangulate with other descendants of Absalom and Elizabeth so as to verify that our relationship is through that line and that the X-match does not come from someone else. It gets tricky with pedigree collapses, and you don’t know what you don’t know until you know it.

Below are two fan charts showing the ancestry of K and me relevant to our discussion. I have put a box around our most recent common ancestors. This chart shows the X inheritance paths as they relate to the newest person in each chart, i.e., K or me. Note that we are at the bottom. Each person who could have passed an X down to get to either of us through this RENFRO/CORMACK line is marked with a red X. You can see that, for example, although K could have, and may have, received X-DNA from Absalom RENFRO, I could not have, so we can’t match with that ancestor on the X.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

In these images, we can visualize what I said earlier about from whom the X-match has to have come.

I hope this has been helpful. Please comment below. Thank you for reading.


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4 thoughts on “Elizabeth (CORMACK) RENFRO – A Nice, Big X Match (Ancestor 45)

  1. My major was biology and one of my favorite classes was genetics, so the geek in me loves this post. However, I am a little interested in your Chromosome 15 match (it jumped out at me) finding for a more personal reason. I think I might have told you that my daughter has Angelman Syndrome? In most cases, it is not genetic and due to a random deletion on the maternally inherited 15th chromosome.

    Yes, my daughter inherited it from me and due to a genetic imprinting error. We were the guinea pigs the researchers waited their entire career to get because there was a mutation between me and my father, but my sister and Dad have identical deletions. Summary: the already mutant 15th chromosome mutated between me and Dad. And to give you an idea how it works, it’s a male-male-female transmission. It came from my Dunn line, but as we all know, it could have been on the Wilson side as a carrier as well. I’ve searched our trees for anyone who might show some signs of this, but way back, it’s probable that the child never survived.

    I have only one other chance to explore, and this is through my dad’s (1st) cousin, S. She has two daughters with disabilities, and it is quite probable that we share this mutation in common.

    I guess I’m wondering if you’ve seen anything in your Wilson research?

    Like

    • Hi, Betsey.

      RE: The Wilson line on my maternal side (for other readers): H.B. and Amanda had an infant (sex unknown) who died at a little over 4 months, and a son Lucian Berry who died at age 9, but infant and child deaths were frequent in most families before the 20th century, as you know. Robert and Nancy Wilson, H. B.’s parents, lost a daughter at age 10, and two infants.

      Do you have an idea on which segments of Chr 15 the mutation occurs? If you/geneticists know this, then you could possibly find the people who match you, your sister, and your dad on Chr 15 in that area. It would be good if you could separate out your maternal Chr 15 matches from the paternal ones. DNA Painter could help a lot with your work here.

      I don’t know of anyone. I can’t recall if there has been anyone over the years at the Wilson Reunions who fits the characteristics of Angelman’s Syndrome.

      Email me if you want to talk more about this. I also find it interesting.

      Elizabeth

      Like

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